In the ending of Casino Royale (1967), Jimmy Bond, who is Dr. Noah, swallows an atomic pill and the casino that hides his base blows up. The film closes on that explosion and sets up no sequel.
Here is how the pieces connect. The casino is introduced as the arena for Evelyn Tremble's baccarat game against Le Chiffre. Tremble wins by exposing Le Chiffre's cheating, is captured and tortured, and is rescued by Vesper Lynd, who later shoots him. The same building then turns out to hide the base of Dr. Noah, who is Bond's nephew Jimmy. In my opinion, that reveal is the film's most disciplined move, because it ties the card table plot and the germ plot into one location, so a single blast can close both.
The earlier set pieces feed the finish. Sir James escapes the traps in the Scottish castle, where SMERSH agents have taken over the household and Agent Mimi fails to seduce him. Mata Bond is carried off by a flying saucer after her trip to Berlin. By the time Sir James and Moneypenny reach the casino, the story has already left spy realism behind, so a nephew who plans a deadly germ plot against men and then swallows an atomic pill is consistent with the film's own logic. The pill is the final application of the cover plan's idea: the villain is tricked, and the trick is the joke.
The production context shows how much the makers invested in this payoff. According to TCM, the climax alone cost $1 million and took two months to shoot, in a film whose budget began at $12 million and grew to more than twice that. The battle brings in Legionnaires, paratroopers and many agents, which is the payoff for the cover plan in which every agent is a James Bond and nobody can tell who is who. The credited cast includes Jean-Paul Belmondo as a French Legionnaire, and the crowd of agents is what the plan promised from the moment Bond decided to multiply himself. As such, it feels closer to a stunt show than a heist, and, in my opinion, that suits a film with five directors (Val Guest, Ken Hughes, John Huston, Joseph McGrath and Robert Parrish) better than a tight plan would.
There is also a gap that the ending cannot close. TCM reports that Peter Sellers refused to appear in scenes with Orson Welles, so the stars playing Tremble and Le Chiffre were never filmed together. The baccarat duel that sets the plot moving therefore has no on-set meeting of its two leads, and the finale hands the closing moments to Jimmy Bond and the crowd instead.
Compared with the series, the contrast is in how the story ends. This is one of two unofficial, non EON entries, at release order 26, outside the 25 official films. The official Casino Royale (2006) sits at release order 21 and is a separate adaptation of the same novel, not a remake of this spoof. Goldfinger is an official film built around one villain and one hero, so it makes a cleaner comparison for anyone who wants that shape. If you want the odd cousin of the series, this one rewards patience. The other unofficial entry, Never Say Never Again, is a different kind of outsider, at release order 27.