In No Time to Die, retired James Bond is drawn back by Felix Leiter to find a kidnapped scientist, learns that a DNA-targeting nanobot weapon is being used by Lyutsifer Safin, and dies in a missile strike on Safin's island after being infected in a way that makes touching his family fatal to them.
Madeleine Swann witnesses the murder of her mother by Safin, who wants revenge on her father, and Safin later pulls her out of a frozen lake. In the present, Bond takes Madeleine to Vesper Lynd's grave, an ambush follows, and he leaves her, thinking she betrayed him.
Five years later, Leiter recruits the retired Bond to rescue the scientist Valdo Obruchev, who created Project Heracles, a nanobot weapon that targets people by their DNA. At a SPECTRE gathering in Cuba, the nanobots are turned on the attendees. Afterward, Leiter's colleague Logan Ash reveals himself as a traitor, and Leiter is killed.
Bond then learns that MI6 itself created the weapon, and that a new agent, Nomi, now holds the 007 number. Ernst Stavro Blofeld, held in prison, is the key to Safin's plan, and Madeleine is made to carry a lethal infection to him. Bond learns that he is infected, so he cannot safely touch the people he loves. Blofeld dies from the nanobots in Bond's blood.
Bond finds Madeleine again in Norway and meets her young daughter Mathilde, whom he comes to understand is his own child. Safin kidnaps Madeleine and Mathilde and takes them to his island base, where the nanobots are made. Bond and Nomi infiltrate the island, and Bond helps Madeleine and Mathilde escape. He arranges for M (Ralph Fiennes) to order a missile strike on the facility.
Safin shoots Bond and infects him with nanobots tuned to Madeleine and Mathilde, and Bond kills Safin. Knowing he can never touch his family again, Bond stays behind and tells Madeleine he loves her. He dies as the missiles destroy the island.
