In Spider-Man (2002), Peter Parker gains spider powers, loses his uncle Ben Parker, and defeats Norman Osborn's Green Goblin on the Queensboro Bridge, but he turns away Mary Jane Watson to protect her.
After the spider bite, Peter uses his powers for money at first, and he lets a thief escape. That thief later kills Uncle Ben, and the loss changes Peter's attitude completely. He builds a costume and starts fighting crime in New York as Spider-Man, while the press, led by editor J. Jonah Jameson, treats him as a menace.
Meanwhile, Peter's friend Harry Osborn is the son of Norman Osborn, who runs the weapons company Oscorp. Under pressure from his board, Norman Osborn tests a performance enhancing formula on himself. It gives him great strength but unstable behavior, and he becomes the Green Goblin. The Goblin kills members of the Oscorp board at a city festival, then turns on Spider-Man and the people close to him.
Peter's feelings for Mary Jane grow even as Harry Osborn starts dating her. The Goblin captures Mary Jane and takes her to the Queensboro Bridge, where Spider-Man fights him. Norman Osborn is killed by his own glider during the fight, and Peter keeps his rival's secret by hiding the evidence. Harry Osborn blames Spider-Man for his father's death and vows revenge. Mary Jane admits she loves Peter, but he turns her away to keep her safe, remembering his uncle's advice about power and responsibility.