The ending of Predators (2010) suggests the hunt is a cycle, and the survivors have escaped one round of it without escaping the planet. Royce and Isabelle kill Berserker, introduce themselves properly for the first time, and then see more parachutes falling from the sky. New victims are arriving, and the two head deeper into the jungle to look for a way home.
What do the parachutes mean? In my opinion, they are the smartest image in the film, because they replay the opening for an audience that now understands it. The first time, a falling Royce was a mystery. The second time, the chutes are a verdict: the preserve restocks itself, and the humans were never the first or the last batch. It could be argued that the film is also leaving the door open for more stories on the same planet, which fits with Rodriguez having pitched a third Predator film as far back as 1994, when Fox passed because the budget was too high.
Why does Edwin matter so much? Edwin looks like the innocent of the group, the doctor who cannot fight. The reveal, after he paralyzes Isabelle, that he is a serial killer who intends to stay, turns him from prey into a second predator. His death by his own scalpel is tidy justice. Royce's return is just as telling, because Berserker had appeared to end him when it destroyed the captive's ship as it lifted off, and he still comes back for Isabelle. For a mercenary who began the film leading by self interest, that is the character arc in one beat.
There is also a pattern in how the film spends its cast. Noland smothering the group with smoke, Nikolai's mines, Stans buying time and Hanzo's sword duel with Falconer each work as a small set piece that removes a different kind of fighter. By the time Royce faces Berserker, he has only Isabelle, which is why the final kill is shared.
Compared with Predator (1987), where Dutch leads a team of mercenary soldiers against one hunter in a Central American jungle, this ending reverses the logic. Here the hunters are the hosts, the humans are the cargo, and the jungle is not home. Predator 2 moved the hunt to a Los Angeles heat wave, so Predators is the entry that finally takes the contest to the hunters' ground. Paradoxically, that makes the final shot feel smaller than the first film's, because there is no helicopter and no rescue, only a longer walk.