Naru wins by turning the Predator's own equipment against it, and in my opinion the finale of Prey (2022) works because the film has already taught her every trick she uses. She lures the creature into the same kind of bog she survived earlier, and she uses the last trapper as bait rather than trying to outfight a hunter that is bigger and better armed. Compare that with predator 1987, where a squad of mercenary soldiers goes into the jungle with rifles and loses. Here the hunted party is one healer, so the film has to win by cunning.
The herbs are the clearest piece of setup. Naru's healer skills help hide Raphael's body heat from the creature, which is a direct answer to the thermal vision the saga established in 1987. Raphael still dies, even after Naru has taught him to shoot the flintlock pistol and he has taught her to shoot it too, and that scene matters: it shows the cloak and the weapons can be beaten but not casually. It could be argued that this is the film's central idea, because the healer who was told she could not hunt wins through plants and terrain, not strength.
The creature's design supports the same reading. Dan Trachtenberg has said he wanted something more feral and animal like than the 1980s suit look, and Dane DiLiegro, who is 6 feet 9 inches tall, gives it a physical presence that reads as a predator in the animal sense. Den of Geek also reports that most scenes used natural light and the night scenes only torchlight, so the bog fight stays dark and tense without the neon gadget glow of later entries such as predators 2010.
The homecoming closes the arc. Naru returns carrying the trophy, is named a war chief, and then tells the tribe it is time to move on. Perhaps that last line is the real ending, because she advises her people to relocate in case more danger comes. The end credits point the same way, with ledger style art of several Predator ships descending toward the tribe.
As a prequel, that image links the film to Predator (1987) and to the anthology predator killer of killers, which sits first in chronological order and, according to Gizmodo, reveals Naru in stasis at its end. Prey (2022) sits second, as covered on predator timeline. Compared with predator badlands, which follows a Yautja hero, this is the one entry where the human is the protagonist and the creature stays an unexplained threat.