In 1942, Hydra leader Johann Schmidt takes the Tesseract from a church in occupied Norway. In Brooklyn, frail Steve Rogers is turned down by the Army again and again until Dr. Erskine offers him a place in an experimental program. The serum works, but a Hydra spy kills Erskine and the formula is lost, leaving Rogers as the only super soldier.
The Army first uses him as a stage mascot called Captain America to sell war bonds. Everything changes when he learns that his friend Bucky Barnes and other soldiers have been captured. Rogers goes behind enemy lines and frees them, then forms a team, the Howling Commandos, to raid Hydra bases one by one. Schmidt, who has revealed his Red Skull face, plans to use the Tesseract's power to attack major cities.
During a mission, Bucky falls from a train and is believed dead. Rogers and the Commandos reach Schmidt's last base, and Rogers boards the giant bomber that is meant to hit the United States. Schmidt grabs the Tesseract, its energy consumes him, and he vanishes. Rogers cannot safely land the plane, so he crashes it into the Arctic and says goodbye to Peggy by radio.
Decades later he wakes in a room that looks like the 1940s, realizes it is a setup, and runs out into modern Times Square. There he meets Nick Fury, who tells him he has been frozen for almost 70 years.