Edward Norton plays Will Graham in Red Dragon (2002), the FBI agent who caught Lecter in 1980 and retired to Florida before Jack Crawford pulls him back for the Tooth Fairy case. Fox News reported that after the New York premiere at the Ziegfeld, Norton hosted 300 paying guests of his family's Enterprise Foundation at the party in Grand Central Station.
Anthony Hopkins plays Hannibal Lecter in Red Dragon (2002), his third time in the role after The Silence of the Lambs (1991) and Hannibal (2001), and Fox News reported that his answer on playing him again was "No more." Hopkins told Philstar he had to look 10 years younger and lost 25 pounds training six days a week, while the Lawrence Journal-World reported that no computer work was used on him and credited diet, exercise and genes.
Ralph Fiennes plays Francis Dolarhyde in Red Dragon (2002), the killer known as the Tooth Fairy. Fiennes told UPI he expected a cardboard cutout psychopath and credited Ted Tally's script with developing Dolarhyde. The Lawrence Journal-World reported that his tattoo, applied by Ken Diaz, took seven to eight hours a session, with two or three sessions in total for his four shooting days with it.
Emily Watson as Reba McClane
Emily Watson plays Reba McClane in Red Dragon (2002), a blind woman who grows close to Francis Dolarhyde. Screen Daily's October 2002 coverage placed her in the main cast alongside Hopkins, Norton and Fiennes. In a UPI interview before release, Fiennes called his screen partner a great actress and a sweetheart, saying she just wants to do the work.
Harvey Keitel plays Jack Crawford in Red Dragon (2002), the FBI chief who persuades Will Graham to leave retirement and join the hunt for the Tooth Fairy. Screen Daily described the part as Graham's Bureau boss, and Fox News listed Keitel among the main cast when the film opened in New York.
Philip Seymour Hoffman plays Freddy Lounds in Red Dragon (2002), a tabloid reporter chasing the Tooth Fairy story. Screen Daily described Lounds as a seedy tabloid reporter and noted that Hoffman and Watson both had relatively small parts. Fiennes, talking about the film with UPI, mentioned Hoffman's reporter and said audiences laughed at some scenes he himself found disturbing.
Anthony Heald plays Dr. Chilton in Red Dragon (2002), the director of the hospital where Lecter is held, returning to the role he first played in The Silence of the Lambs (1991). Heald told The A.V. Club that the production recreated the original set and had a wig made for him, because he had a buzz cut for Boston Public.
Mary-Louise Parker as Molly Graham
Mary-Louise Parker plays Molly Graham in Red Dragon (2002), Will's wife, who has built a quiet life with him and their son in Florida. Screen Daily listed Parker in the main cast in October 2002, and Fox News named her among the ensemble at the film's release.
Tyler Patrick Jones as Josh Graham
Tyler Patrick Jones plays Josh Graham, the young son of Will and Molly. TMDB gives his birthday as March 12, 1994, which made him eight when Red Dragon opened in October 2002. His TMDB credits show Minority Report the same year, then Bad News Bears and Yours, Mine & Ours in 2005, and a ten episode run on Ghost Whisperer.
Ken Leung plays Lloyd Bowman in Red Dragon (2002), part of the FBI team working the Tooth Fairy case. His TMDB credits show he had already worked with Brett Ratner as Sang in Rush Hour (1998). He worked with Ratner again on X-Men: The Last Stand (2006) and later played Miles Straume on Lost.
Frankie Faison plays Barney in Red Dragon (2002), the orderly on Lecter's ward, a role he first played in The Silence of the Lambs (1991) and repeated in Hannibal (2001). TMDB also credits Faison as Lt. Fisk in Manhunter (1986), and he told The A.V. Club that he is the only actor who appears in all four films, adding that not even Anthony Hopkins can claim that.
Lalo Schifrin appears on screen in Red Dragon (2002) as the Conductor. TMDB lists him as composer of Brett Ratner's Rush Hour (1998) and of the Mission: Impossible main title theme, while Danny Elfman scored Red Dragon. TMDB lists Red Dragon as his only acting role outside documentaries and concerts, and records his death on June 26, 2025.