Vin Diesel plays Dominic Toretto, who is raising his young son with Letty when his crew pulls him back into the field. Diesel is also one of the film's producers. Speaking to UPI in June 2021, he said he never pictured Dom as a father when the first film started in 2001, and that F9 shows how committed Dom has become to fatherhood.
Michelle Rodriguez plays Letty Ortiz, who is living a quiet family life with Dom at the start of the film until Project Aries draws them both back in. UPI's June 2021 coverage notes that Letty and Dom are raising the son introduced in The Fate of the Furious, and that Letty had recovered from the amnesia storyline of the later sequels.
Tyrese Gibson returns as Roman Pearce, the crew member who usually talks first and plans later. In a June 2021 interview with UPI, Gibson said F9 let Roman be more dramatic instead of serving only as comic relief. In this film Roman starts to wonder whether the team is somehow immortal, since none of them has died after so many missions.
Ludacris plays Tej Parker, who works alongside Roman and Ramsey for much of the mission. TheWrap listed him among the announced cast in August 2019, when filming was already underway. UPI's coverage describes Tej mocking Roman's theory that the crew cannot be killed, a running joke through their scenes together in this film.
John Cena plays Jakob Toretto, Dom's estranged brother, whom Dom has not forgiven since their father died in a racing crash. Universal confirmed Cena's casting in June 2019, after Vin Diesel had hinted at it on Instagram that April. Diesel later told UPI that for Jakob, the whole world was considered before Cena got the part.
Nathalie Emmanuel plays Ramsey, who rejoins the crew in the hunt for Project Aries. F9 is her third film in the series as Ramsey. Emmanuel told UPI that Ramsey has become a foil to Roman and Tej, and that she enjoys putting the two of them in their place.
Jordana Brewster returns as Mia Toretto, Dom's sister, after the character was absent from The Fate of the Furious. In F9, Mia leaves Brian at home with the children and joins Dom to deal with Jakob. Brewster told UPI that a woman leaving her husband and kids behind for a mission felt refreshing and evolved.
Sung Kang plays Han Lue, who had been presumed dead since Tokyo Drift, and F9 explains how he survived. TheWrap reported in January 2020 that the first trailer revealed his return. Kang told UPI he only felt comfortable coming back because Justin Lin was directing again, and that Han now looks after the newcomer Elle.
Michael Rooker plays Buddy, one of the new characters in F9. Deadline first reported the casting, and TheWrap confirmed it on August 19, 2019, describing it as a small role added while production was already underway. When Rooker joined, John Cena, Charlize Theron and Helen Mirren had already been announced, along with the returning core crew.
Helen Mirren plays Queenie Shaw, the mother of Deckard Shaw, returning to the role she first played in The Fate of the Furious (2017). Vin Diesel announced her return on social media during filming, saying Oscar winners such as Charlize Theron and Helen Mirren were with the cast. Slashfilm reported the announcement.
Kurt Russell returns as Mr. Nobody, the head of a secret organization that TheWrap says has been tangled up with the family since Furious 7. In F9 the plane carrying him and Cipher is attacked at the start of the story. The attack sets the mission in motion, and the fate of Mr. Nobody is left unknown.
Charlize Theron plays Cipher, the villain the crew first faced in The Fate of the Furious (2017), where both she and Helen Mirren made their franchise debuts. Vin Diesel announced her return from the set during filming in 2019. TheWrap confirmed her return in its January 2020 report on the first trailer, and the attack on the plane carrying her opens the plot.