The full plot of Halloween Resurrection runs from Laurie Strode's death in the opening scenes to Michael Myers' apparent defeat in a fiery fight inside his own house. Spoilers for the whole story follow, so skip ahead if you have not seen the film.
Laurie lives in a psychiatric facility, convinced that the man she beheaded years earlier was not really Michael. Michael appears at the facility and confronts her. She does not survive the encounter, which means the series' lead character is gone before the main story begins. The film also supplies an explanation for how Michael survived, by disguising himself as a paramedic, and that storyline is credited to Kevin Williamson.
A year later, producers Freddie Harris and Nora Winston run an internet show that sends six students into the Myers house. Sara, Rudy, Donna, Jen, Jim and Bill enter with cameras on their bodies and on the walls. Freddie and Nora use staged tricks to frighten them, which keeps the online audience watching and keeps the students guessing which scares are real.
Michael, who really is inside, begins killing the students one by one. The viewers online assume it is part of the act, so the deaths are being watched as entertainment while they happen. Deckard, a fan watching the live feed on his computer, realizes the murders are real and tries to warn Sara by message. His warnings turn the reality show format against itself, because the only person who sees the truth is a viewer sitting far away.
Freddie finally understands the danger and goes back into the house to help. Sara and Freddie try to escape, and Deckard meets up with them. Freddie fights Michael and sets him on fire in an electrical blaze. Michael seems to be dead and is taken to a morgue. Sara and Deckard are safe, and the film cuts to its final scene.