In the ending, Clarice kills Jame Gumb in his dark basement and saves Catherine Martin, graduates from the FBI Academy, and then takes a phone call from a free Hannibal Lecter, who follows Dr. Chilton through a crowd in a tropical setting. The film closes the case and leaves its most dangerous character at large.
In my opinion, the two halves of that ending pull in different directions on purpose. The basement scene is the payoff for the whole investigation: Gumb cuts the lights and hunts Clarice with night vision goggles, and he loses only because he gives away his position. She wins by listening in the dark, which echoes the way she was forced to listen to Lecter earlier. The graduation call then undercuts the celebration. Lecter makes clear that he will not hunt her, so he is a threat she can live beside, which is arguably more unsettling than a villain who wants her dead.
The Chilton line is a punchline with a sting. Lecter tells Clarice he is going to have an old friend for dinner, and then he follows Dr. Chilton. Perhaps the film wants you to laugh, and then wonder why you did.
The open ending set up the later stories. Hannibal (2001) picks up ten years after the Buffalo Bill case with Julianne Moore as Clarice, and Red Dragon (2002) and Hannibal Rising go back to earlier chapters. For how the movies differ from the books, see hannibal lecter books vs movies. Anyone asking about a Silence of the Lambs 2 is looking for Hannibal (2001), and a Silence of the Lambs 3 is not a title in the saga. As of November 2026, no studio has announced a dated new Lecter film, and the new hannibal movie page tracks that.