Tara survives the opening attack, and Sam returns to Woodsboro with Richie. Sam is hiding a secret: she is the daughter of Billy Loomis, the killer from the first film, and she is troubled by visions of him.
The killer then works through people with ties to the old murders and to Tara's circle. Vince is killed, and so is Wes Hicks, along with his mother, Sheriff Judy Hicks. Tara's friends, including the twins Mindy and Chad Meeks-Martin, become the next targets. Former sheriff Dewey Riley is stabbed at the hospital while trying to help, and he dies. Gale Weathers and Sidney Prescott arrive to stand beside the survivors.
The group meets at the house of Amber, which once belonged to Stu Macher. There Amber shoots Liv and is revealed as one of the two killers, with Richie as her partner. Both are fans of the Stab films who wanted to stage new, real murders to inspire a better sequel, and they planned to frame Sam for the killings.
Sidney and Gale fight them. Gale shoots Amber, who is set alight on a stove. Sam kills Richie, and Tara finishes off the wounded Amber. Sam, Tara and their friends survive, and Gale chooses not to write a book about the killings.