Vin Diesel plays Dominic Toretto, who is broken out of a prison bus by Brian and Mia before the three go on the run to Rio de Janeiro. Diesel returns from Fast & Furious (2009) and also works behind the camera on Fast Five, credited as a producer alongside Michael Fottrell and Neal H. Moritz.
Paul Walker plays Brian O'Conner, the former cop who now works with Dom on the opposite side of the law, as the IMAX and Universal announcement of April 25, 2011 described him. Walker returns from Fast & Furious (2009), and in Fast Five Brian and Mia take part in the train heist that first brings the crew into conflict with Reyes.
Jordana Brewster plays Mia Toretto, who helps Brian free her brother from a prison bus and then joins the train heist in Rio that goes wrong. Brewster returns from Fast & Furious (2009), where TMDB bills her fourth, and in Fast Five she moves up to third billing, directly behind Vin Diesel and Paul Walker.
Tyrese Gibson plays Roman Pearce, one of the returning players on Dom and Brian's crew in Rio. Gibson first played the role in 2 Fast 2 Furious (2003), where TMDB bills him second behind Paul Walker, so Fast Five brings Roman back eight years after his first appearance, with Gibson billed fourth.
Ludacris plays Tej Parker, who arrives in Fast Five alongside Roman Pearce. He first played Tej in 2 Fast 2 Furious (2003), billed fifth on TMDB, and the IMAX and Universal announcement of April 25, 2011 lists him as Chris "Ludacris" Bridges among the returning favorites.
Matt Schulze as Vince
Matt Schulze plays Vince, the character he first played in The Fast and the Furious (2001), where TMDB bills him eighth. His return links Fast Five directly to the first film, which came out ten years earlier, and the IMAX and Universal announcement of April 25, 2011 names him among the returning cast.
Sung Kang plays Han Lue, a member of the crew that Dom and Brian work with in Rio. Kang first played Han in The Fast and the Furious: Tokyo Drift (2006), where TMDB bills him third, and then returned in Fast & Furious (2009). Justin Lin directed both of those films as well as Fast Five.
Gal Gadot plays Gisele Yashar, a character she first played in Fast & Furious (2009), where TMDB bills her seventh. She is billed eighth in Fast Five, and the IMAX and Universal announcement of April 25, 2011 lists her among the returning cast, next to Sung Kang and Matt Schulze.
Tego Calderon plays Leo in Fast Five and returns from Fast & Furious (2009), where TMDB credits the character as Tego Leo. On May 26, 2010, when Universal had chosen Puerto Rico for the shoot, Primera Hora reported that Calderon would make a special appearance, and the Rio scenes were then filmed on the island.
Don Omar plays Santos, a character TMDB credits as Rico Santos in Fast & Furious (2009). He is billed tenth in Fast Five, directly after Tego Calderon, and Primera Hora named both men for special appearances in its May 2010 report on a shoot centered on the San Juan metro area.
Joaquim de Almeida plays Reyes, the ruthless Rio crime boss in Fast Five who owns the cars the crew is stealing in the train heist, and whose men capture Dom and Brian before they escape. Reyes is a new character for the saga, and de Almeida is billed eleventh, one place above Dwayne Johnson.
Dwayne Johnson plays Luke Hobbs, the federal agent sent in Fast Five to hunt Dom, Brian and Mia after the three are framed for a killing. In a 2016 fan livestream reported by The A.V. Club, Vin Diesel said the role was first intended for Tommy Lee Jones and was rewritten for Johnson after fans asked for the pairing.